Figure 6.

Intra-prefrontal cortex (PFC) infusion of rapamycin (Rapa) resisted the elevation of mammalian target of Rapa (mTOR) signaling activity in the PFC. Rapa blocked the elevation of phosphorylated (p)-mTOR and p-S6 ribosomal protein (rpS6) levels in the PFC compared with the control groups (a, c). Total mTOR and rpS6 levels were not significantly changed in the PFC (b, d) in the four groups. The data are expressed as mean±SEM. Representative band intensities of the western blot are shown on the bottom (n=6 per group). *p<0.05, compared with the control group; ^#p<0.05, predictable chronic mild stress (PCMS)-Rapa group compared with PCMS-vehicle (Veh) group.