Table 2.
Time-kill results for clinafloxacin and comparator drugs tested at four times the MIC.
| Organism | Log decrease (increase) at endpoint for antibiotic a | |||
|---|---|---|---|---|
| Clina-floxacin | Dano-floxacin | Enro-floxacin | Control | |
| M. haemolytica ATCC 33396 | 4.7 | 4.1 | 4.0 | (2.2) |
| AHDRCC 39227 | 4.8 | 4.2 | 3.9 | (2.3) |
| AHDRCC 39228 | 4.8 | 4.2 | 4.0 | (2.7) |
| P. multocida ATCC 43137 | 4.8 | 4.2 | 4.0 | (2.3) |
| AHDRCC 39571 (cattle) | 4.5 | 4.6 | 4.4 | (3.3) |
| AHDRCC 44344 (swine) | 4.6 | 4.4 | 4.4 | (2.7) |
| H. somni ATCC 700025 | 4.4 | 3.8 | 4.3 | (2.9) |
| AHDRCC 38925 | 4.6 | 4.0 | 4.1 | (2.0) |
| A. pleuropneumoniae | 4.6 | 4.0 | 4.2 | (2.3) |
| ATCC 27090 | ||||
| AHDRCC 44672 | 4.8 | 4.2 | 4.2 | (2.4) |
a
The log CFU per milliliter reduction was calculated at 24 h for all cultures.