Table 4.

Murine drug efficacy assays.

In vivo model (route of infection)	Drugs dosed at:	Mean ED50 value (mg/kg/dose)
		Ceftiofur (n)	Clinafloxacin (n)	Enrofloxacin (n)
Bovine M. haemolytica (IP)	1, 24, and 48 h post-challenge	0.28 (5)	0.019 (5)	0.29 (5)
	1 and 3 h post-challenge	0.22 (2)	0.008 (2)	na
Bovine P. multocida (IN)	18 h post-challenge	1.05 (2)	0. 55 (2)	na
Bovine P. multocida (IP)	1 and 3 h post-challenge	0.11 (3)	0.08 (3)	0.26 (3)
Swine A. pleuropneumoniae (IP)	1, 24, and 48 h post-challenge	8.2 (3)	0.7 (3)	1.8 (3)

IP, intraperitoneal; IN, intranasal; n, number of tests; na, not available.