Figure 3.

TIGAR-Deficient Mice Are More Sensitive to DSS-Induced Colitis

(A) Colon from WT and TIGAR^−/− (KO) animals 2 days after 2% DSS treatment. Top: H&E; bottom: BrdU staining. Bar = 200 μm.

(B) Percentage of colitis area one day after 3.5% DSS in WT and KO animals. ^∗p < 0.05 compared to WT.

(C) Percentage of colitis area one day after 2% DSS in WT and KO animals. ^∗p < 0.05 compared to WT.

(D) Percentage of colitis area 2 days after 2% DSS in WT and KO animals. ^∗p < 0.05 compared to WT.

(E) TIGAR staining in WT animals, untreated (ctr) or after 3.5% DSS treatment. Scale bar, 200 μm. Panels show details of crypt structures indicated in the box.

(F) MDA staining of WT and KO animals before and after 2% DSS treatment. Scale bar, 200 μm. Data are represented as mean ± SEM (n = at least 3).

See also Figure S3.