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. Author manuscript; available in PMC: 2013 Jun 14.
Published in final edited form as: J Immunol. 2009 Feb 15;182(4):2102–2112. doi: 10.4049/jimmunol.0802769

FIGURE 4.

FIGURE 4

PD-L1 inhibits the accumulation of gut-reactive CD8+ T cells. A, Accumulation of transferred CD45.1+ OT-I T cells in lymphoid tissues and small intestines of isotype-treated CD45.2+ C57BL/6 and iFABP-tOVA mice and anti-PD-L1-treated iFABP-tOVA mice. Donor-derived (CD45.1+) OT-I T cells were enumerated 5–7 days posttransfer by flow cytometry. Representative dot plots are shown and values at gate indicate percentage of OT-I T cells among total CD8+ cells. B, Graphic representation of data shown in A for lymph nodes (circles) and intestine (triangles). Data represent the percentage of donor OT-I T cells among total CD8+ T cells as mean ± SD for lymph nodes and small intestine. C, Absolute number of OT-I T cells in lymph nodes from data shown in B. Data represent the mean number ± SD of donor OT-I T cells per 106 lymph node cells for each tissue.