Table 2.

Information of the studied SNPs and allele frequencies between cases and controls in a Spanish population.

		Chromosome				MAF
Gene	SNP ID	Number	Positiona	Nucleotide change	Gene polymorphism	Control n=479	Cases n=398	P value b
THRA	rs939348	17	35485379	C/T	Intron 2	0.25	0.28	0.25
THRB	rs3752874	3	24159999	C/T	Phe245Phe	0.16	0.14	0.23
rs826377	3	24143435	T/C	Intron 9	0.18	0.19	0.91
rs844107	3	24138025	A/G	3′-UTR	0.38	0.37	0.60
TSHR	rs11845164	14	80601507	C/T	Intron 2	0.14	0.15	0.60
	rs8019570	14	80619348	A/G	Intron 3	0.14	0.15	0.58

n, number of subjects; MAF, minor allele frequency; SNP, single nucleotide polymorphisms.

^aPosition according to NCBI reference sequence.

^bTwo-sided χ ² test for distribution of allele frequencies.