Table 3.
Genotype frequencies of the selected SNPs and their association with differentiated thyroid cancer in a Spanish population.
| SNP | Genotype | Control, n (%) | DTC, n (%) | Odds ratio a (95% CI) | P value b | PTC, n (%) | Odds ratio a (95% CI) | P value b | FTC, n (%) | Odds ratio a (95% CI) | P value b |
|---|---|---|---|---|---|---|---|---|---|---|---|
| THRA | |||||||||||
| rs939348 | C/C | 259 (54.2) | 210 (53.2) | 1.00 | 180 (53.6) | 1.00 | 30 (50.9) | 1.00 | |||
| C/T | 196 (41.0) | 151 (38.2) | 0.89 (0.67–1.18) | 130 (38.7) | 0.90 (0.67–1.21) | 21 (35.6) | 0.84 (0.46–1.53) | ||||
| T/T | 23 (4.8) | 34 (8.6) | 1.71 (0.97–3.03) | 0.082 | 26 (7.7) | 1.59 (0.87–2.91) | 0.19 | 8 (13.6) | 2.51 (1.01–6.24) | 0.098 | |
| C/C+C/T−T/T | 23 (4.8) | 34 (8.6) | 1.80 (1.03–3.14) | 0.037 c | 26 (7.7) | 1.66 (0.92–3.01) | 0.092 c | 8 (13.6) | 2.70 (1.12–6.49) | 0.037 c | |
| THRB | |||||||||||
| rs3752874 | C/C | 331 (69.2) | 287 (72.7) | 1.00 | 246 (73.0) | 1.00 | 41 (70.7) | 1.00 | |||
| C/T | 138 (28.9) | 103 (26.1) | 0.85 (0.63–1.16) | 86 (25.5) | 0.83 (0.60–1.14) | 17 (29.3) | 1.05 (0.57–1.93) | ||||
| T/T | 9 (1.9) | 5 (1.3) | 0.63 (0.21–1.95) | 0.45 | 5 (1.5) | 0.73 (0.24–2.25) | 0.47 | 0 (0.0) | 0.00 (0.00–NA) | 0.39 | |
| rs826377 | T/T | 320 (67.0) | 260 (65.8) | 1.00 | 223 (66.4) | 1.00 | 37 (62.7) | 1.00 | |||
| T/C | 141 (29.5) | 124 (31.4) | 1.06 (0.79–1.43) | 103 (30.6) | 1.03 (0.75–1.41) | 21 (35.6) | 1.29 (0.72–2.30) | ||||
| C/C | 17 (3.6) | 11 (2.8) | 0.77 (0.35–1.69) | 0.72 | 10 (3.0) | 0.83 (0.37–1.87) | 0.87 | 1 (1.7) | 0.50 (0.06–3.93) | 0.50 | |
| rs844107 | A/A | 178 (38.5) | 158 (40.8) | 1.00 | 135 (40.7) | 1.00 | 23 (41.1) | 1.00 | |||
| A/G | 219 (47.4) | 176 (45.1) | 0.89 (0.66–1.21) | 155 (46.7) | 0.93 (0.68–1.26) | 21 (37.5) | 0.79 (0.42–1.49) | ||||
| G/G | 65 (14.1) | 54 (14.1) | 0.92 (0.60–1.41) | 0.76 | 42 (12.7) | 0.83 (0.52–1.31) | 0.71 | 12 (21.4) | 1.47 (0.68–3.14) | 0.31 | |
| TSHR | |||||||||||
| rs11845164 | T/T | 347 (73.0) | 287 (72.7) | 1.00 | 242 (71.8) | 1.00 | 45 (77.6) | 1.00 | |||
| T/C | 122 (25.7) | 97 (24.6) | 0.97 (0.71–1.33) | 86 (25.5) | 1.02 (0.74–1.42) | 11 (19.0) | 0.71 (0.35–1.44) | ||||
| C/C | 6 (1.3) | 11 (2.8) | 2.22 (0.79–6.24) | 0.29 | 9 (2.7) | 2.08 (0.71–6.06) | 0.4 | 2 (3.5) | 2.66 (0.50–14.10) | 0.32 | |
| rs8019570 | G/G | 352 (73.6) | 288 (72.9) | 1.00 | 243 (72.3) | 1.00 | 45 (76.3) | 1.00 | |||
| G/A | 120 (25.1) | 97 (24.6) | 1.00 (0.73–1.37) | 85 (25.3) | 1.04 (0.75–1.44) | 12 (20.3) | 0.80 (0.41–1.58) | ||||
| A/A | 6 (1.3) | 10 (2.5) | 2.08 (0.73–5.96) | 0.38 | 8 (2.4) | 1.90 (0.64–5.70) | 0.51 | 2 (3.4) | 2.70 (0.51–14.26) | 0.42 |
PTC, papillary thyroid cancer; FTC, follicular thyroid cancer.
a
Adjusted for age and gender.
b
P value corresponding to co-dominant model.
c
P value corresponding to recessive model. P<0.05.