Table 2.
Physiological data
| Day 1 | Day 2 | Day 3 | Day 4 | |
|---|---|---|---|---|
| MAP, mmHg | 75 ± 9 | 77 ± 11 | 80 ± 7 | 83 ± 10 |
| Mx | 0.42 (0.05, 0.96) |
0.39 (0.12, 0.97) |
0.22 (-0.53, 0.88) |
0.28 (-0.36, 0.84) |
| CI, l/min/m2 | 3.7 (2.3, 7.5) |
3.8 (2.6, 5.3) |
3.8 (2.3, 7.3) |
4.1 (2.7, 7.7) |
| HR, min-1 | 100 ± 20 | 92 ± 17 | 87 ± 15 | 97 ± 19 |
| Norepinephrine, µg/kg/min | 0.34 (0.06, 1.64) n = 30 |
0.29 (0.03, 1.04) n = 30 |
0.19 (0.04, 0.73) n = 27 |
0.17 (0.02, 0.67) n = 18 |
| Dobutamine, µg/kg/min | 2,98 (0.69, 6.55) n = 15 |
2.91 (0.16, 8.20) n = 19 |
2.05 (0.33, 8.30) n = 19 |
3.13 (0.52, 5.13) n = 15 |
| Epinephrine, µg/kg/min | 0.11 (0.04, 3.90) n = 6 |
0.15 (0.13, 0.18) n = 2 |
n = 0 | n = 0 |
| Propofol, mg/kg/h | 2.1 ± 0.9 | 1.8 ± 0.7 | 1.6 ± 0.7 | 1.4 ± 0.8 |
| Sufentanil, µg/kg/min | 0.3 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 |
| Core temperature, °C | 37.2 ± 1.1 | 37.2 ± 1.0 | 37.2 ± 1.0 | 37.4 ± 0.9 |
| CBFV, cm/s | 52 (19, 94) |
52 (13, 125) |
60 (20, 108) |
53 (14, 104) |
| paO2, kPa | 15.2 ± 3.9 | 14.2 ± 3.6 | 15.3 ± 3.6 | 14.0 ± 2.8 |
| paCO2, kPa | 5.7 ± 1.2 | 5.9 ± 0.9 | 6.0 ± 1.1 | 6.4 ± 1.2 |
| CRP, mg/l | 209 (44, 491) |
308 (31, 478) |
214 (26, 397) |
146 (16, 329) |
| PCT, ng/ml | 23.5 (1.1, 409.0) |
14.0 (2.0, 390.0) |
8.5 (1.2, 44.0) |
6.2 (0.8, 42.0) |
| NSE, ng/ml | 15.8 (7.1, 40.3) |
15.1 (7.0, 65.3) |
12.6 (6.5, 28.0) |
10.7 (3.2, 47.5) |
| S100, ng/ml | 0.23 (0.11, 3.79) |
0.21 (0.07, 0.59) |
0.17 (0.07, 0.66) |
0.15 (0.05, 0.49) |
| SOFA, score | 12 ± 3 | 12 ± 3 | 11 ± 3 | 10 ± 4 |
Values are given as mean ± standard deviation or median (minimum, maximum) for distorted data. MAP, mean arterial blood pressure; Mx, autoregulation index; CI, cardiac index; HR, heart rate; n, number of counts of patients needing norepinephrine, dobutamine, and epinephrine; CBFV, cerebral blood flow velocity; paO2, arterial partial pressure of oxygen; paCO2, arterial partial pressure of carbon dioxide; CRP, C-reactive protein; PCT, procalcitonin; NSE, neuron-specific enolase; SOFA, Sequential Organ Failure Assessment.