Table 2.
Multivariate analysis of propofol administration and diagnosis of full or partial posttraumatic stress disorder (PTSD) at 1 and 6 months after a motor vehicle accident
| PTSD diagnosis | Logistic regression at 1 month | Logistic regression at 6 months | |||||
|---|---|---|---|---|---|---|---|
| Covariates | OR | 95% CI | P-value | OR | 95% CI | P-value | |
| Full or partial | Propofol | 1.31 | 0.41, 4.23 | 0.647 | 6.13 | 1.57, 23.85 | 0.009 |
| Age | 0.99 | 0.97, 1.01 | 0.397 | 1.04 | 1.00, 1.07 | 0.032 | |
| Female | 10.02 | 4.33, 23.17 | < 0.001 | 5.76 | 1.97, 16.78 | 0.001 | |
| ISS | 1.10 | 1.05, 1.15 | < 0.001 | 1.04 | 0.98, 1.11 | 0.217 | |
| Midazolam | 0.46 | 0.12, 1.69 | 0.240 | 0.40 | 0.06, 2.73 | 0.349 | |
| Ketamin | 1.91 | 0.62, 5.94 | 0.262 | 1.15 | 0.20, 6.51 | 0.878 | |
| Full | Propofol | 0.90 | 0.09, 8.98 | 0.928 | 14.63 | 2.07, 103.29 | 0.007 |
| Age | 1.04 | 0.99, 1.08 | 0.128 | 1.01 | 0.96, 1.06 | 0.819 | |
| Female | 7.53 | 1.65, 34.44 | 0.009 | 5.16 | 0.99, 27.04 | 0.052 | |
| ISS | 1.07 | 0.98, 1.17 | 0.112 | 0.94 | 0.82, 1.07 | 0.352 | |
| Midazolam | 0.42 | 0.02, 7.61 | 0.555 | 0.51 | 0.02, 12.08 | 0.673 | |
| Ketamine | 0.96 | 0.07, 14.00 | 0.974 | 1.19 | 0.06, 23.97 | 0.909 | |
The independent variable was use of propofol within 72 h of a motor vehicle accident (MVA); n = 300 participants analyzed by multivariate logistic regression analysis of age, female sex, and administration of ketamine or midazolam within 72 h of an MVA. OR, odds ratio; ISS, injury severity score.