Table 2.
Quality indicators and assessment of risk of bias in the included randomized controlled trials
| Quality indicators/studies | Shaw and colleagues [23] | Vajkoczy and colleagues [24] | CONSCIOUS-1 [25] | CONSCIOUS-2 [16] | CONSCIOUS-3 [26] |
|---|---|---|---|---|---|
| Randomized controlled study | Yes | Yes | Yes | Yes | Yes |
| Appropriate random sequence generation | Yes | Unclear | Unclear | Yes | Yes |
| Allocation concealment | Unclear | Unclear | Unclear | Yes | Yes |
| Blinding of participants and personnel | Yes | Yes | Yes | Yes | Yes |
| Blinding of outcome assessment | Unclear | Yes | Yes | Yes | Yes |
| Explanation for withdrawals and dropouts | No | Yes | Yes | Yes | Yes |
| Jadad scale | 4 | 4 | 4 | 5 | 5 |