Table 1. Patient demographic, and baseline ophthalmic and lesion criteria, for 48 patients included in the efficacy evaluations.

Parameter		Results
Demographic characteristics
Mean age, years (SD)		56.8 (14.39)
Age distribution, n (%)
<50 years		14 (29.2)
50 to <65 years		22 (45.8)
65 to <75 years		9 (18.8)
75+ years		3 (6.3)
Gender, n (%)
Female		35 (72.9)
Male		13 (27.1)
Ethnic origin, n (%)
Caucasian		44 (91.7)
Other		4 (8.3)
Mean weight, kg		78.14
Mean PM duration, years (SD)		40.45 (21.42)
Median PM duration, years		46.86
Mean CNV duration, months (SD)		1.8 (3.36)
Median CNV duration, months		0.6
Baseline ophthalmic characteristics
Mean VA letters (SD)		58.6 (14.63)
Median visual VA letters		61
Patients, n (%)
<23 Letters		1 (2.1)
23–37 Letters		4 (8.3)
38–52 Letters		9 (18.8)
53–67 Letters		20 (41.7)
68–82 Letters		13 (27.1)
>82 Letters		1 (2.1)
Mean CMT, μm (SD)		365.5 (111.60)
Median CMT, μm		375.0
Study eye worse than fellow eye (%)		72.9
Baseline lesion criteria (clinician reported)
Criteria	No	Yes	Questionable
Intraretinal oedema with centre involvement, n (%)	4 (8.3)	44 (91.7)	NA
Intraretinal cysts, n (%)	12 (25.0)	28 (58.3)	8 (16.7)
Subretinal fluid, n (%)	11 (22.9)	31 (64.6)	6 (12.5)
Subretinal/intraretinal haemorrhage, n (%)	18 (37.5)	29 (60.4)	1 (2.1)
CNV location, n (%)
N/A		1 (2.1)
Subfoveal		32 (66.7)
Juxtafoveal		11 (22.9)
Probably subfoveal/juxtafoveal		4 (8.3)
Mean area of lesion, mm2 (SD)		1.459 (1.392)
Median area of lesion, mm2		1.080

Abbreviations: CMT, central macular thickness; CNV, choroidal neovascularisation; N/A, not available; PM, pathological myopia; SD, standard deviation; VA, visual acuity.

Baseline lesion criteria data are derived from the full safety data set.