Figure 5.

Temperature increase does not produce detectable TRPV1-mediated background current in hippocampal pyramidal neurons. A, Top traces, Voltage-clamp recordings obtained at ∼39°C from a CA1 pyramidal cell in control conditions and in the presence of bath-applied SB366791 (10 μm); bottom trace, voltage protocol. B, Offline digital subtraction of the trace in SB366791 from the control trace shows no evidence for a TRPV1-sensitive background current at ∼39°C (4 cells). C, Bar chart summary of the background current recorded at ∼39°C in control conditions and in the presence of SB366791 (SB).