Figure 11.
Effect of degree of cholinergic deafferentation on auditory localization performance. Proportion of correct responses (averaged over all loudspeaker locations) at five different stimulus durations for all animals with bilateral ME20.4-SAP immunotoxin injections in the NB, ordered by the percentage of loss of p75NTR-IR neurons in the NB relative to control animals (see Table 2). Increasing cholinergic deafferentation led to progressively greater performance deficits, particularly at shorter stimulus durations. The degree of performance impairment positively correlated with the extent of cholinergic cell loss in the NB. Values plotted are means ± SD.