Table 2.
Relationship between cholinergic cell loss in the NB after bilateral ME20.4-SAP injections and behavioral performance in individual animals
| Animal ID | % p75NTR-IR cells lost in the NB |
Sound localization accuracy (40 ms) | Response bias at end of monaural occlusion | Response gain at end of monaural occlusion | Regression slope during monaural occlusion (100×) | ||
|---|---|---|---|---|---|---|---|
| Left | Right | Mean | |||||
| F0942 (×) | 33% | 30% | 31.5% | 49 ± 3% | 0.078 | 0.685 | 1.7 |
| F0940 (●) | 75% | 11% | 43% | 44 ± 5% | 0.023 | 0.561 | 2.4 |
| F0952 (◆) | 83% | 86% | 84.5% | 32 ± 6% | 0.099 | 0.482 | 0.1 |
| F0953 | 95% | 77% | 86% | 32 ± 3% | |||
| F0941 (▴) | 84% | 95% | 89.5% | 34 ± 3% | −0.212 | 0.354 | 1.3 |
| F0954 (■) | 97% | 98% | 97.5% | 38 ± 5% | 0.291 | 0.438 | 2.1 |
| F0857 | 16% | 2% | 9% | 51 ± 5% | |||
The percentage of p75NTR-IR neurons lost in each hemisphere and the average loss are shown together with the percentage of correct responses (mean ± SD across all loudspeaker locations) on the sound localization task for 40 ms noise bursts, the response bias and gain in the relationship between stimulus and approach-to-target response location at the end of a 9–10 d period of monaural occlusion, and the slope of the linear regression of percentage correct score versus training day during this period. The monaural occlusion experiments were performed in five of these animals using 1000 ms noise bursts, as indicated by the symbols in the first column, which correspond to those used in Figure 5.