Table 2. Initial and Average Heme Tilt Angle Calculated for CYP3A4 in Five Independent Membrane-Binding Simulations^a.

run	initial tilt angle (deg)	avg tilt angle (deg)
Mem-1	55.2	75.9 (3.9)
Mem-2	33.9	69.1 (5.3)
Mem-3	51.9	72.9 (3.7)
Mem-4	59.9	74.4 (5.0)
Mem-5	81.0	68.7 (3.7)
avg		72.2 (3.2)

^aAverages were calculated from the last 40 ns of each simulation corresponding to the membrane-bound form of CYP3A4. Standard deviations are given in parentheses.