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Sub-chronic administration of semagacestat (twice daily 100 mg/kg, p. o. over 12 days, n = 4, RED symbols) significantly attenuated absolute (A) and relative (B) power of hippocampal theta oscillation elicited by stimulation of the nucleus pontis oralis with increasing currents (0–0.2 mA) compared to vehicle-treated control C57BL/6 mice (n = 4; BLUE symbols; *p < 0.05). In contrast, no significant difference in peak frequency in elicited theta activity was noticed (C).
