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Time-frequency decomposition of representative hippocampal recordings from two mice treated with vehicle (A,B)or semagacestat (100 mg/kg; C,D) approximately 30 min after start of recordings as indicated by white arrows. Note the strong and persistent low frequency (<2 Hz) component of the ongoing oscillation pattern in the semagacestat-treated animals, which unlike in the case of vehicle-treated animals does not give place to the regular 4–5 Hz theta rhythm during stimulation periods.
