Table 2.
SNP | Chromosome | Posision | Allele (minor/ major) | Gene | Predicted function | Discovery Chinese sample | Replication Caucasian sample | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||
MAF | Bivariate p | MAF | Bivariate p | ||||||||
ALM-HBS | ALM-ABS | ALM-HBS | ALM-ABS | ||||||||
rs4325816 | 2 | 174517145 | C/T | SP3 | intronic | 0.02 | 2.55E-03 | 7.68E-06 | 0.22 | - | - |
rs4145971 | 4 | 44537971 | T/G | RP11-55C6.1 | non-coding | 0.25 | 5.27E-07 | - | 0.25 | - | - |
rs961719 | 4 | 80247809 | C/G | non-coding intronic | 0.10 | 1.01E-05 | 6.24E-07 | 0.45 | - | - | |
rs12648730 | 4 | 80278147 | G/A | RP11-438E5.1 | non-coding intronic | 0.10 | 7.95E-06 | 6.70E-07 | 0.45 | - | - |
rs1584984 | 4 | 80279231 | A/G | non-coding intronic | 0.10 | 6.24E-06 | 3.43E-07 | 0.29 | - | - | |
rs11008640 | 10 | 32124485 | G/C | ARHGAP12 | 3′ donwstream | 0.50 | - | 3.93E-06 | 0.19 | - | - |
rs2768331 | 10 | 119245685 | C/G | EMX2OS | 5′ upstream | 0.25 | 8.15E-06 | - | 0.22 | - | - |
rs2507838 | 11 | 58229375 | A/C | intronic | 0.05 | 1.90E-03 | 2.06E-06 | 0.03 | 5.14E-03 | 3.71E-04 | |
rs7116722 | 11 | 58263484 | T/G | GLYAT | 3′ donwstream | 0.05 | 7.52E-04 | 1.75E-06 | 0.02 | 1.03E-02 | 2.23E-03 |
rs11826261 | 11 | 58271739 | A/G | 3′ donwstream | 0.05 | 3.16E-03 | 1.75E-06 | 0.02 | 1.11E-02 | 1.89E-03 | |
rs10505721 | 12 | 1075963 | G/A | ERC1 | intronic | 0.18 | 6.44E-07 | - | 0.13 | - | - |
rs11068990 | 12 | 117471566 | G/A | RP11-121J20.1-001 | 3′ donwstream | 0.03 | 2.52E-05 | 6.62E-06 | 0.11 | - | - |
rs12891306 | 14 | 35967587 | G/A | SFTA3 | 3′ donwstream | 0.22 | 7.04E-06 | - | 0.39 | - | - |
rs901130 | 15 | 72360960 | C/G | CCDC33 | intronic | 0.48 | 2.22E-03 | 5.10E-06 | 0.29 | - | - |
| |||||||||||
Phenotype correlation coefficient | 0.50* | 0.88* | 0.54* | 0.84* |
Note: - p > 0.05,
p < 0.001,
ALM appendicular lean mass, BSP bone size phenotype, HBS hip bone size, ABS appendicular bone size.