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. Author manuscript; available in PMC: 2013 Jun 14.
Published in final edited form as: Pharmacol Ther. 2008 Dec 24;122(1):9–18. doi: 10.1016/j.pharmthera.2008.12.001

Fig. 3.

Fig. 3

GDNF attenuates ethanol-mediated induction of TH protein levels. (A) Exposure to ethanol leads to the formation of a complex between HSP90 and TH via the activation of the cyclic AMP-dependent protein kinase A (cAMP/PKA) pathway, resulting in the stabilization and accumulation of TH protein. (B) GDNF reverses this ethanol-mediated adaptation by inhibition of the association between TH and HSP90, leading to the reduction in TH protein stability.