TABLE 2.
Balance Between Corneal Pro-angiogenic and Anti-angiogenic Factors
| Corneal Pro-angiogenic Factors | Corneal Anti-angiogenic Factors |
|---|---|
| VEGF-A | Sflt-1 |
| bFGF | Angiostatin |
| PDGF | Endostatin |
| aFGF | Neostatin-7 and -14 |
| NRP-1 | PEDF |
| Ang1 and 2 | Restin |
| IL-8 | Prolactin |
| IL-1β | SPARC |
| HGF | TSP-1 and -2 |
| PDGFR | Calreticulen |
| TGF-β | TIMP |
| Endoglin | |
| Plasminogen activator | |
| Galectin-3 | |
| Ephrin-B2 |
Modified with permission from Ellenberg et al.1
PEDF, pigment epithelium–derived factor; PDGF, platelet-derived growth factor PDGFR, platelet-derived growth factor receptor; aFGF, acidic fibroblast growth factor; NRP-1, neuropilin 1; IL, interleukin; HGF, hepatocyte growth factor; TGF-B, transforming growth factor beta; Sflt-1, soluble fms-like tyrosine kinase-1; SPARC, secreted protein, acidic, and rich in cysteine; TSP, thrombospondin; TIMP, tissue inhibitor of metalloproteinase 1.