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Structural representations of BLIP-II-TEM-1 (red; Protein Data Bank 1JTD) and BLIP-II-Bla1 (cyan; Protein Data Bank 3QHY) interactions (27, 28). The selected interactions of the BLIP-II hot spots and specificity determinants with TEM-1 and Bla1 β-lactamase are shown including Phe-73 and Tyr-74 (A), Trp-269 (B), Trp-53 (C), and Asp-206 (D).
