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Structural sequence alignment of V-NAR E06 and its humanized variants with human germ line Vκ light chain DPK9/Jκ1, shark V-NAR 5A7, and a humanized 5A7 variant, 5A7-IVabc. DPK9 framework residues and residues in V-NARs identical to DPK9 are shown in green. Mutations in E06 HV4 are shown in blue. The residue numbering refers to the E06 sequence.
