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. 2013 Apr 29;288(24):17460–17471. doi: 10.1074/jbc.M113.468405

FIGURE 5.

FIGURE 5.

Gene expression in response to HAMLET or oleate (500 μm). 549 lung carcinoma cells were treated with HAMLET (35 μm) or oleate (500 μm), and RNA was harvested after 1 h. A, shown is a heatmap of the top 200 differentially expressed genes (log 2-fold change >1 and p value < 0.05). B, shown are up- and down-regulated genes for HAMLET and oleate 500 samples. More genes were differentially regulated for oleate 500 compared with HAMLET. C, a Venn diagram shows unique and overlapping genes in HAMLET or oleate 500 samples. D, shown are shared or specific canonical pathways regulated by HAMLET or oleate. E, top genes unique to HAMLET and oleate 500 are shown. F, shown is a network of cancer-related genes differentially regulated by oleate 500. Expression values from the oleate sample were overlaid onto the same network, showing that most genes were not differentially regulated in the HAMLET sample. Down-regulated genes were colored in green, and up-regulated genes are in red.