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Model for MLL5-mediated cell cycle control. MLL5 form a complex with HCF-1 and OGT, and then was recruited to E2F1 responsive promoters (CYCLIN A, CDC2, and CDC6) to stimulate H3K4 trimethylation and cause transcriptional activation of E2F1 target genes to facilitate the G1 to S phase transition. See text for details.
