Cisplatin produces time-dependent behavioral sensitization to mechanical and cold stimulation. Time course of development of (a,b) mechanical and (c,d) cold allodynia in NaHCO3/cisplatin or saline/cisplatin-treated groups relative to control/saline-treated control group. Groups received 3 (a,c) or 4 (b,d) once weekly injections and were monitored for 16 or 28 days, respectively. Data are expressed as mean ± s.e.m. (n = 8–44 per group). * P < 0.0001 vs. control/saline group.