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Creatinine (a,b) and ketone (c,d) levels are increased in saline/cisplatin relative to control/saline or NaHCO3/cisplatin-treated groups. Animals received 3 or 4 once weekly injections over 16 (a,c,e) or 28 (b,d,f) days. Glucose levels did not differ in any group in either dosing paradigm (e,f). Data are expressed as mean ± s.e.m. (n = 8–9 per group). * P < 0.0001 vs. control/saline group; + P < 0.0001 vs NaHCO3/Cisplatin group.
