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. Author manuscript; available in PMC: 2013 Jun 14.
Published in final edited form as: Tuberculosis (Edinb). 2009 Dec;89(0 1):S18–S25. doi: 10.1016/S1472-9792(09)70007-1

Fig. 3.

Fig. 3

Overcoming natural resistance of MTB to antibiotics.21 The combination of CRL-1072 with each drug reduced CFUs in lungs below the levels achieved by the drug alone. The combinations of CRL-1072 with isoniazid (INH), rifampin (RIF), streptomycin (SM) and pyrazinamide (PZA) produced significant bactericidal effects while the antibiotic alone was only mildly bacteriostatic. Ethambutol (ETH) had a significant bacteriostatic effect. Top horizontal line = 28 day growth in untreated controls. The lower horizontal line = CFU counts at day 0 baseline.