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. Author manuscript; available in PMC: 2013 Jun 14.
Published in final edited form as: Prog Retin Eye Res. 2008 May 28;27(4):331–371. doi: 10.1016/j.preteyeres.2008.05.001

Figure 10.

Figure 10

High glucose treatment of EC leads to superoxide formation, an increase in intracellular calcium and activation of endothelial NOS (NOS3) to form NO, but it also causes NOS3 “uncoupling” to generate superoxide and NO.