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Effect of a Pitolisant (5 mg·kg−1, i.p.) pretreatment on the time course (A) and cumulated horizontal locomotor activity over 90 min (B) of vehicle or cocaine-treated (10 mg·kg−1, s.c.) mice. Mean ± SEM of 23 to 42 mice. Statistical comparison of cumulated locomotor activity over the 90-min period was performed by anova followed by a PLSD Fisher test: F(2,103) = 9.625, P = 0.0001 with ⋆P < 0.05 versus cocaine group.
