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Venous plasma NO2− concentration (μM) in (A) non-infused arm and (B) infused arm in normal subjects (open symbols) and CHF patients (closed symbols). Baseline NO2− concentrations were marginally lower in CHF patients than in normal subjects (P = 0.08). NO2− concentrations rose significantly (F = 32.7; P < 0.0001) with NO2− infusion in the infused arm: this increase was attenuated significantly (F = 10.6; P = 0.002) in CHF patients. * = P < 0.05 versus normal subjects.
