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. 2013 May 16;169(3):704–716. doi: 10.1111/bph.12150

Figure 3.

Figure 3

Use-dependent and ramp currents. A shows the average use-dependent inactivation of currents at pH 7.4 control (filled circles, n = 20), 10 μM ranolazine (filled squares, n = 6) and 100 μM ranolazine (filled diamonds, n = 7) over 500 traces at 10 Hz. Sample ramp currents elicited by a 500 ms depolarization from −130 to 20 mV are shown at pH 7.4 in control (Black) and after 100 μM ranolazine perfusion (Gray) in B. C shows the average use-dependent inactivation of currents at pH 6.0 control (open circles, n = 22), 10 μM ranolazine (open squares, n = 7) and 100 μM ranolazine (open diamonds, n = 8) over 500 traces at 10 Hz. C inset shows the concentration dependence of use-dependent block developed by the 500th pulse in a train of 10 Hz depolarizations to 0 mV at pH 7.4 (closed squares) and pH 6.0 (open squares). Sample ramp currents elicited by a 500 ms depolarization from −130 to 20 mV are shown at pH 6.0 in control (Black) and after 100 μM ranolazine perfusion (grey) in D. Time constants and asymptotes of use-dependent inactivation are in Table 4.