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. 2013 May 16;169(3):704–716. doi: 10.1111/bph.12150

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British Journal of Pharmacology © 2013 The British Pharmacological Society

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Recovery from slow inactivation and ranolazine block. A shows the recovery from slow inactivation and ranolazine block after a 4 s onset at pH 7.4 control (filled circles, n = 6), 10 μM ranolazine (filled squares, n = 7) and 100 μM ranolazine (filled diamonds, n = 6). Recovery from slow inactivation and ranolazine block after a 32 second onset at pH 7.4 control (filled circles, n = 8), 10 μM ranolazine (filled squares, n = 7) and 100 μM ranolazine (filled diamonds, n = 6) are shown in B. C shows the recovery from slow inactivation and ranolazine block after a 4 s onset at pH 6.0 control (open circles, n = 5), 10 μM ranolazine (open squares, n = 6) and 100 μM ranolazine (open diamonds, n = 7). Recovery from slow inactivation and ranolazine block after a 32 s onset at pH 6.0 control (open circles, n = 6), 10 μM ranolazine (open squares, n = 6) and 100 μM ranolazine (open diamonds, n = 7) are shown in D. Time constants, amplitudes and asymptotes are in Table 7. All insets show the initial 5 s of recovery in their respective condition.