Table 2.

Open-state fast inactivation

	FI Onset τ −20 mV	FI Onset τ −10 mV	FIOnset τ 0 mV	FI Onset τ 10 mV
pH 7.4
NaV1.2	1.63 ± 0.12 ms	0.83 ± 0.04 ms	0.56 ± 0.02 ms	0.43 ± 0.02 ms
NaV1.2 with 100 μM Ranolazine	1.34 ± 0.12 ms*1	0.75 ± 0.04 ms*1	0.52 ± 0.02 ms	0.41 ± 0.02 ms
pH 6.0
NaV1.2	2.98 ± 0.28 ms*1	1.42 ± 0.12 ms*1	0.73 ± 0.06 ms	0.49 ± 0.03 ms
NaV1.2 with 100 μM Ranolazine	2.19 ± 0.18 ms*3*4	1.04 ± 0.08 ms*3*4	0.58 ± 0.04 ms*4	0.42 ± 0.03 ms*4

^*1= P < 0.05 versus pH 7.4 without drug.

^*3= P < 0.05 versus pH 7.4 with 100 μM Ranolazine.

^*4= P < 0.05 versus pH 6.0 without drug.