Table 3.
Fast inactivation recovery
| FI Recovery τ 1 | FI Recovery A1 | FI Recovery τ 2 | FI Recovery A2 | |
|---|---|---|---|---|
| pH 7.4 | ||||
| NaV1.2 | 1.2 ± 0.1 ms | 0.79 ± 0.02 | 48.5 ± 7.9 ms | 0.20 ± 0.02 |
| NaV1.2 with 100 μM Ranolazine | 2.2 ± 0.4 ms*1 | 0.48 ± 0.03*1 | 325.1 ± 21.8 ms*1 | 0.51 ± 0.03*1 |
| pH 6.0 | ||||
| NaV1.2 | 1.1 ± 0.1 ms | 0.79 ± 0.02 | 24.5 ± 5.8 ms*1 | 0.14 ± 0.02 |
| NaV1.2 with 100 μM Ranolazine | 2.2 ± 0.3 ms*4 | 0.75 ± 0.04*3 | 53.7 ± 12.2 ms*3*4 | 0.24 ± 0.04*3 |
*1
= P < 0.05 versus pH 7.4 without drug.
*3
= P < 0.05 versus pH 7.4 with 100 μM Ranolazine.
*4
= P < 0.05 versus pH 6.0 without drug.