Table 5.

Steady-state slow inactivation

	SSSI V1/2	SSSI z
pH 7.4
NaV1.2	−53.9 ± 2.5 mV	−4.8 ± 0.3
NaV1.2 with 10 μM Ranolazine	−62.1 ± 2.1 mV*1	−4.7 ± 0.3
NaV1.2 with 100 μM Ranolazine	−66.7 ± 2.4 mV*1	−4.9 ± 0.5
pH 6.0
NaV1.2	−46.1 ± 1.7 mV*1	−4.8 ± 0.3
NaV1.2 with 10 μM Ranolazine	−50.7 ± 2.2 mV*2	−4.1 ± 0.3
NaV1.2 with 100 μM Ranolazine	−63.8 ± 4.5 mV*4*5	−4.0 ± 0.4

^*1= P < 0.05 versus pH 7.4 without drug.

^*2= P < 0.05 versus pH 7.4 with 10 μM Ranolazine.

^*4= P < 0.05 versus pH 6.0 without drug.

^*5= P < 0.05 versus pH 6.0 with 10 μM Ranolazine.