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. 2013 May 16;169(3):704–716. doi: 10.1111/bph.12150

Table 5.

Steady-state slow inactivation

SSSI V1/2 SSSI z
pH 7.4
NaV1.2 −53.9 ± 2.5 mV −4.8 ± 0.3
NaV1.2 with 10 μM Ranolazine −62.1 ± 2.1 mV*1 −4.7 ± 0.3
NaV1.2 with 100 μM Ranolazine −66.7 ± 2.4 mV*1 −4.9 ± 0.5
pH 6.0
NaV1.2 −46.1 ± 1.7 mV*1 −4.8 ± 0.3
NaV1.2 with 10 μM Ranolazine −50.7 ± 2.2 mV*2 −4.1 ± 0.3
NaV1.2 with 100 μM Ranolazine −63.8 ± 4.5 mV*4*5 −4.0 ± 0.4
*1

= P < 0.05 versus pH 7.4 without drug.

*2

= P < 0.05 versus pH 7.4 with 10 μM Ranolazine.

*4

= P < 0.05 versus pH 6.0 without drug.

*5

= P < 0.05 versus pH 6.0 with 10 μM Ranolazine.