Table 6.

Slow inactivation onset

	SI Onset Y0 (500 ms)	SI Onset τ (500 ms)	SI Onset A (500 ms)	SI Onset Y0 (2 s)	SI Onset τ (2 s)	SI Onset A (2 s)
pH 7.4
NaV1.2	0.52 ± 0.05	19.4 ± 2.6 s	0.42 ± 0.05	n/a	n/a	n/a
NaV1.2 with 10 μM Ranolazine	0.32 ± 0.04*1	9.4 ± 1.2 s*1	0.58 ± 0.03*1	0.65 ± 0.03	25.3 ± 3.8 s	0.30 ± 0.04
NaV1.2 with 100 μM Ranolazine	0.19 ± 0.04*1	3.1 ± 0.3 s*1*2	0.44 ± 0.03*2	0.64 ± 0.04	11.5 ± 2.8 s*2	0.22 ± 0.02
pH 6.0
NaV1.2	0.58 ± 0.05	15.1 ± 3.1 s	0.36 ± 0.04	n/a	n/a	n/a
NaV1.2 with 10 μM Ranolazine	0.31 ± 0.04*4	19.3 ± 2.6 s*2	0.60 ± 0.04*4	0.41 ± 0.07*2	34.3 ± 6.2 s	0.51 ± 0.07*2
NaV1.2 with 100 μM Ranolazine	0.07 ± 0.02*3*4*5	10.2 ± 1.6 s*3	0.77 ± 0.04*3*4*5	0.25 ± 0.06*3	11.5 ± 2.2 s*5	0.61 ± 0.05*3

^*1= P < 0.05 versus pH 7.4 without drug.

^*2= P < 0.05 versus pH 7.4 with 10 μM Ranolazine.

^*3= P < 0.05 versus pH 7.4 with 100 μM Ranolazine.

^*4= P < 0.05 versus pH 6.0 without drug.

^*5= P < 0.05 versus pH 6.0 with 10 μM Ranolazine.