Table 7.

Slow inactivation recovery

	SI Recovery τ 1 (4 s)	SI Recovery A 1 (4 s)	SI Recovery τ 2 (4 s)	SI Recovery A 2 (4 s)	SI Recovery τ 1 (32 s)	SI Recovery A 1 (32 s)	SI Recovery τ 2 (32 s)	SI Recovery A 2 (32 s)
pH 7.4
NaV1.2	116 ± 8 ms	0.55 ± 0.04	4.2 ± 1.3 s	0.14 ± 0.03	266 ± 63 ms	0.71 ± 0.04	6.3 ± 1.1 s	0.27 ± 0.04
NaV1.2 with 10 μM Ranolazine	324 ± 89 ms	0.67 ± 0.06	5.77 ± 2.87 s	0.17 ± 0.05	933 ± 190 ms*1	0.78 ± 0.07	9.0 ± 3.3 s	0.22 ± 0.06
NaV1.2 with 100 μM Ranolazine	1080 ± 89 ms*1*2	0.94 ± 0.02*1*2	37.2 ± 26 s*1*2	0.07 ± 0.02*2	1450 ± 150 ms*1*2	0.73 ± 0.03	18.4 ± 4.3 s*1*2	0.24 ± 0.03
pH 6.0
NaV1.2	104 ± 26 ms	0.44 ± 0.05	2.7 ± 0.8 s	0.24 ± 0.05	213 ± 60 ms	0.60 ± 0.03*1	5.7 ± 1.2 s	0.29 ± 0.03
NaV1.2 with 10 μM Ranolazine	108 ± 34 ms	0.49 ± 0.07	6.1 ± 2.8 s	0.23 ± 0.01	340 ± 89 ms*2	0.54 ± 0.03	13.6 ± 1.6 s*2*4	0.44 ± 0.03*4
NaV1.2 with 100 μM Ranolazine	134 ± 27 ms*3	0.45 ± 0.04*3	19.7 ± 2.3 s*4*5	0.39 ± 0.03*3*4*5	606 ± 128 ms*3*4	0.18 ± 0.03*3*4*5	16.3 ± 1.3 s*4	0.83 ± 0.03*3*4*5

^*1= P < 0.05 versus pH 7.4 without drug.

^*2= P < 0.05 versus pH 7.4 with 10 μM Ranolazine.

^*3= P < 0.05 versus pH 7.4 with 100 μM Ranolazine.

^*4= P < 0.05 versus pH 6.0 without drug.

^*5= P < 0.05 versus pH 6.0 with 10 μM Ranolazine.