Table 1.
Summary of studies on master regulators that generate regions of open chromatin enabling the recruitment of stimulus-activated TFs in different cell types.
| cell type | master regulator | stimulus | stimulus-activated TFs | references |
|---|---|---|---|---|
| dendritic cells | Pu.1 | LPS | NF-κB, STATs, AP-1, IRFs | [36] |
| LNCaP (prostate epithelium) | FoxA1 | 5α-dihydrotestosterone | AR | [37] |
| MCF-7 (breast epithelium) | FoxA1 | tamoxifen, oestradiol | ERα | [38] |
| MCF-7 (breast epithelium) | FoxA1, AP2γ | oestradiol | ERα | [39] |
| U2OS (osteoblast-like cells) | GATA4 | oestradiol | ERα | [40] |
| 3134 (breast epithelium) | AP-1 | dexamethasone | GR | [41] |
| ESCs | OCT4 | TGFβ | Smad2/3 | [42] |
| myotubes | Myo-D | TGFβ | Smad2/3 | [42] |
| Pro-B cells | Pu.1 | TGFβ | Smad2/3 | [42] |
| macrophages | Pu.1 | LPS | Bcl-6 | [31] |
| macrophages | Pu.1 | LPS | NF-κB | [10] |