. Author manuscript; available in PMC: 2013 Jun 14.

Published in final edited form as: Medchemcomm. 2012 Jun;3(6):720–724. doi: 10.1039/C2MD00318J

Table 1.

Inhibition of tubulin polymerization and colchicine binding.

Compound	Inhibition of tubulin polymerization IC₅₀ (µM)	Inhibition of Colchicine binding (%)^a

		5µM	1µM
CA1	1.9^b	nd^c	nd
CA4	1.2^b,^d	100	88
1	1.7^e	nd	nd
3	1.2	91	65
4	2.5	63	nd

Reaction mixtures contained 1 µM tubulin, 5µM [³H]colchicine, and inhibitor as indicated

See ref 34.

nd = not determined in this study.

See ref 35.

See ref 1.