Table 3.
Histopathologic reports
| Covariates | Nonrecurrence (n = 107 ) | Recurrence (n = 120 ) | P-value |
|---|---|---|---|
| Histologic types | 0.848 | ||
| Adenocarcinoma | 61 (57.0) | 72 (60.0) | |
| Squamous cell carcinoma | 29 (27.1) | 32 (26.7) | |
| Others* | 17 (15.9) | 16 (13.3) | |
| Tumor grading | 0.644 | ||
| Well differentiated | 34 (31.8) | 48 (40.0) | |
| Moderately differentiated | 45 (42.1) | 44 (36.7) | |
| Poorly differentiated | 18 (16.8) | 22 (18.3) | |
| Undifferentiated | 4 (3.7) | 3 (2.5) | |
| Mucinous type of adenocarcinoma in situ | 3 (2.8) | 2 (1.7) | |
| Nonmucinous type of adenocarcinoma in situ | 3 (2.8) | 1 (0.8) | |
| Pathological staging | 0.041 | ||
| IA | 20 (18.7) | 13 (10.8) | |
| IB | 25 (23.4) | 21 (17.5) | |
| IIA | 17 (15.9) | 21 (17.5) | |
| IIB | 19 (17.8) | 12 (10.0) | |
| IIIA | 24 (23.4) | 51 (42.5) | |
| IIIB | 1 (0.9) | 2 (1.7) | |
| Tumor diameter (cm) | 0.325 | ||
| ≤5 | 75 (70.1) | 76 (63.3) | |
| >5 | 32 (29.9) | 44 (36.7) | |
| Nodal involvement | 0.003 | ||
| Nodal negative | 72 (67.3) | 57 (47.5) | |
| Nodal positive# | 35 (32.7) | 63 (52.5) | |
| Tumor necrosis | 36 (33.6) | 56 (46.7) | 0.058 |
| Visceral pleural invasion | 19 (17.8) | 29 (24.2) | 0.258 |
| Neural invasion | 3 (2.8) | 6 (5.0) | 0.506 |
| Intratumoral lymphatic invasion | 84 (78.5) | 104 (86.7) | 0.115 |
| Intratumoral blood vessel invasion | 32 (29.9) | 64 (53.3) | <0.001 |
Notes:
*
Other cell types include adenocarcinoma in situ,24 large cell carcinoma, neuroendocrine tumor, adenoid cystic carcinoma, metastasis, mucoepidermoid carcinoma, lymphoepithelioma-like carcinoma, adenosquamous cell carcinoma;
#
nodal positive refers to the presence of malignant cells, in any node level (1–14).