Table 1.

Effects of PPARα-agonists on PPAR transcriptional activity

Compound		Aleglitazar[26]	GFT505[48]	K-877[52]	Fenofibrate[26,52]
PPARα	EC50 (nM)	5	10 to 20	1	14,000 [52]; 22,400 [26]
PPARγ	EC50 (nM)	9	NA	2,300	~100,000
PPARδ	EC50 (nM)	376	100 to 150	1,000	not activated

EC50 effective concentration inducing 50% response; NA not available.