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Modified and unmodified siRNA off-target effects. cWords word cluster plots showing 6, 7, and 8mer words enriched in 3′UTRs of genes downregulated by siRNA off-target binding after transfection of an unmodified (B) and 2-O-methyl modified (C) siRNA targeting Pik3ca. Enrichment of the 6mer seed (bases 2–7, AAAGCC) of the siRNA is highlighted in bold letters and seed region is illustrated in panel (A).
