Table 1. Associations between SNPs and either aPTT or APC resistance.

Trait	SNP	Chra	Positionb	Gene symbolc	Tested allele	N	Ln effectd (95% CI)	Effect in secondse(95% CI)	P-valuef
aPTT	rs2545801	5	176773945	F12	A	2498	0.05 (0.04, 0.06)	1.05 (1.04, 1.06)	1.39 × 10−59
aPTT	rs1801020	5	176769138	F12	A	2505	0.05 (0.05, 0.06)	1.05 (1.05, 1.06)	1.55 × 10−59
aPTT	rs17876032	5	176763233	F12	G	2507	0.04 (0.03, 0.04)	1.04 (1.03, 1.04)	1.40 × 10−37
aPTT	rs710446	3	187942621	KNG1	G	2501	−0.03 (−0.03, −0.02)	0.97 (0.97, 0.98)	2.68 × 10−19
aPTT	rs2228243	3	187877807	HRG	G	2503	0.03 (0.02, 0.04)	1.03 (1.02, 1.04)	1.35 × 10−17
aPTT	rs16860992	3	187876732	HRG	C	2503	0.03 (0.02, 0.04)	1.03 (1.02, 1.04)	4.37 × 10−17
aPTT	rs5030062	3	187936874	KNG1	C	2506	−0.02 (−0.03, −0.02)	0.98 (0.97, 0.98)	3.55 × 10−15
aPTT	rs1621816	3	187921867	KNG1	G	2500	0.02 (0.02, 0.03)	1.02 (1.02, 1.03)	2.33 × 10−14
aPTT	rs5030028	3	187928448	KNG1	A	2502	0.03 (0.02, 0.03)	1.03 (1.02, 1.03)	3.78 × 10−14
aPTT	rs5030023	3	187927338	KNG1	A	2508	0.03 (0.02, 0.03)	1.03 (1.02, 1.03)	4.16 × 10−14
aPTT	rs3856930	3	187941016	KNG1	A	2506	−0.02 (−0.03, −0.02)	0.98 (0.97, 0.98)	6.90 × 10−14
aPTT	rs1624230	3	187921629	KNG1	A	2499	0.02 (0.02,0.03)	1.02 (1.02, 1.03)	9.47 × 10−14
aPTT	rs657152	9	135129086	ABO	A	2507	−0.02 (−0.03,−0.01)	0.98 (0.97, 0.99)	2.45 × 10−11
aPTT	rs266723	3	187929741	KNG1	C	2501	0.02 (0.01, 0.02)	1.02 (1.01, 1.02)	3.31 × 10−10
aPTT	rs7447593	5	176756743	F12	C	2504	−0.02 (−0.02, −0.01)	0.98 (0.98, 0.99)	1.81 × 10−09
aPTT	rs7381103	5	176770918	F12	G	2510	0.05 (0.03, 0.07)	1.05 (1.03, 1.07)	4.35 × 10−09
aPTT	rs651007	9	135143696	ABO	A	2502	−0.02 (−0.03, −0.01)	0.98 (0.97, 0.99)	5.97 × 10−09
aPTT	rs1042445	3	187878130	HRG	A	2508	−0.02 (−0.03, −0.01)	0.98 (0.97, 0.99)	2.27 × 10−08
aPTT	rs1624569	3	187932763	KNG1	G	2499	0.02 (0.01, 0.02)	1.02 (1.01, 1.02)	5.15 × 10−08
aPTT	rs2062632	3	187943875	KNG1	G	2503	0.02 (0.01, 0.02)	1.02 (1.01, 1.02)	1.04 × 10−07
aPTT	rs2287694	5	176792899	GRK6	G	2508	0.02 (0.02, 0.03)	1.02 (1.02, 1.03)	1.39 × 10−07
aPTT	rs4253304	4	187410565	KLKB1	C	2498	−0.01 (−0.02, −0.01)	0.99 (0.98, 0.99)	1.67 × 10−07
aPTT	rs13177732	5	176789531	GRK6	C	2500	−0.02 (−0.02, −0.01)	0.98 (0.98, 0.99)	2.56 × 10−07
aPTT	rs9898	3	187873321	HRG	A	2505	0.02 (0.01, 0.02)	1.02 (1.01, 1.02)	2.61 × 10−07
aPTT	rs2304595	4	187409274	KLKB1	A	2507	−0.01 (−0.02, −0.01)	0.99 (0.98, 0.99)	3.60 × 10−07
aPTT	rs5030091	3	187943571	KNG1	G	2507	0.01 (0.01, 0.02)	1.01 (1.01, 1.02)	7.29 × 10−07
APC-R	rs6025	1	1.68E+08	F5	A	2500	−0.28 (−0.31, −0.26)	0.76 (0.73, 0.77)	4.2 × 10−104
APC-R	rs6682179	1	1.68E+08	F5	A	2499	−0.08 (−0.1, −0.07)	0.92 (0.9, 1.07)	1.43 × 10−28
APC-R	rs6427196	1	1.68E+08	F5	C	2500	−0.08 (−0.1, −0.07)	0.92 (0.9, 1.07)	2.11 × 10−28
APC-R	rs6009	1	1.68E+08	F5	A	2500	−0.08 (−0.1, −0.07)	0.92 (0.9, 1.07)	1.24 × 10−27
APC-R	rs16860992	3	1.88E+08	HRG	C	2492	0.04 (0.03, 0.04)	1.04 (1.03, 1.04)	2.29 × 10−15
APC-R	rs2228243	3	1.88E+08	HRG	G	2492	0.03 (0.03, 0.04)	1.03 (1.03, 1.04)	9.55 × 10−15
APC-R	rs9898	3	1.88E+08	HRG	A	2496	0.02 (0.02, 0.03)	1.02 (1.02, 1.03)	5.26 × 10−11
APC-R	rs2038024	1	1.68E+08	SLC19A2	C	2496	−0.03 (−0.04, −0.02)	0.97 (0.96, 0.98)	1.75 × 10−09

^aChromosome (‘Chr').

^bChromosomal position.

^cMapped gene.

^dLogged effect sizes (as tested by regression).

^eAnti-logged effect sizes (for direct interpretation), where effect is change in trait per tested allele.

^fP-value indicates strength of evidence against the null hypothesis as tested by linear regression of trait on number of tested alleles.

Both aPTT and APC resistance (‘traits') are presented in this table.