Table 3.
Gene name | Chr. position | Gene description | p-value, p53 functional vs., p53 non functional |
---|---|---|---|
PRKCZ |
1p36.33-p36.2 |
Serine threonine kinase involved in several processes such as proliferation, differentiation and secretion. |
4.95E-04 |
|
|
|
↑non functional |
LMO3 |
12p12.3 |
Lim domain only 3 (rhombotin like 2). Expression of LMO-3 represses p53 mediated mRNA expression of target genes. |
1.2E-02 |
↑non functional | |||
CDKN1A |
6p21.2 |
Cyclin dependent kinase inhibitor. Causes cell cycle arrest in the presence of DNA damage. |
1.3E-02↑functional |
PDE6A |
5q31.2-q34 |
Phosphodiesterase 6A, cGMP-specific, rod, alpha |
7.47E-02 |
↑non functional | |||
SIAH1 |
16q12 |
Seven in absentia homolog 1. Involved in ubiquitination and proteosome related degradation of specific proteins like beta catenin. |
2.60E-02 |
↑non functional | |||
TPD52L2 |
20q13.2-q13.3 |
Tumor protein D52 like 2. Expressed in childhood leukemia and testes. |
4.65E-02 |
↑non functional | |||
MDM2 |
12q14.3-q15 |
MDM2 p53 binding protein homolog (Mouse) |
1.25E-02 |
↑ functional | |||
HMGCS1 | 5p14-p13 | 3-hydroxy 3-methylglutaryl-CoA synthase I | 1E-01 |
↑functional |
All p-values are corrected for multiple tests.