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EWS-FLI1’s transcriptional targets
| Transcriptional regulators | Signaling pathway regulation | Cell cycle | Metabolism | Angiogenesis-extracellular matrix |
|---|---|---|---|---|
| EZH2 | IGFBP3 | Cyclin E | Uridine phosphorylase | VEGF-A |
| NR0B1 | PTPL1 | p21 | GSTM4 | MMP-1 |
| GLI1 | Caveolin | P57KIP* | — | PLD2 |
| Id2 | hTERT | CYCLIN D1* | — | Tenascin C |
| EGR1 | TGFβRII | — | — | — |
| NKX2.2* | AURKA | — | — | — |
| — | PDGFC* | — | — | — |
Indirect targets of EWS-FLI1.
