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. 2013 Jun 14;8(6):e65381. doi: 10.1371/journal.pone.0065381

Figure 5. Activated protein kinases related to UP induced apoptosis.

Figure 5

A. Effects of exposure of P388 cells to 0.05 µM UP for 1 h on the phosphorylation status and expression level of protein kinases. The expression was quantified using the computerized image analysis system ImageQuant. Each column represents those scanned in duplicate of three wells expressed as percentage of control ± Standard Deviation. ***, P<0.001, UP vs. Control. B. Effects of MAPK inhibitors on UP-induced P388 growth inhibition,the cells were pretreated with U0126 (10 µM), SP60012 (20 µM) or SB203580 (20 µM) for 1 h, then co-treated with UP for 72 h. U0126, ERK inhibitor; SP60012(SP), JNK inhibitor; SB203580(SB), P38 inhibitor. **, P<0.01, PG vs.(PG+inhibitor),UP vs.(UP+ inhibitor).