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Female BALB/c mice (6−8 wk old, five mice per group) were intramuscularly immunized with 20 µg of recombinant HA proteins over a 3-week interval. Immunized mice were intranasally challenged with 10× MLD50 H5N1 virus (NIBRG-14) 3 wk after their second inoculations. Survival rates (A) and body weights (B) were recorded for 14 d. Body weight loss over 25% was used as an end-point. Body weight loss is presented as mean ± standard deviation.
