Table 2. General characteristics and biological parameters.
| Normal | Sham | MI | MI+los | P | |
|---|---|---|---|---|---|
| 3 week (n) | 8 | 8 | 14 | 20 | |
| Body weight (g) | 281.0±4.10 | 297.2±8.84 | 318.2±6.95 a | 332.4±7.92 a | <0.001 |
| Renal weight (g) | 1.92±0.04 | 1.92±0.05 | 2.00±0.06 | 2.10±0.08 | 0.261 |
| Renal weight/body weight (*10-3) | 6.84±0.19 | 6.49±0.27 | 6.30±0.12 | 6.30±0.14 | 0.149 |
| Heart rate (beat/min) | 353±22 | 363±23 | 359±8 | 384±12 | 0.324 |
| Systolic blood pressure (mmHg) | 127±5 | 134±4 | 120±2 | 100±3 abc | <0.001 |
| Diastolic blood pressure (mmHg) | 97±4 | 96±4 | 91±2 | 78±3 abc | <0.001 |
| Ejection fraction (%) | 61.9±0.85 | 63.9±2.01 | 28.5±1.44 ab | 35.2±2.59 ab | <0.001 |
| Blood glucose (mmol/L) | 6.2±0.46 | 6.2±0.64 | 4.6±0.08 | 5.8±0.22 | 0.021 |
| 9 week (n) | 8 | 10 | 10 | 18 | |
| Body weight (g) | 346.7±6.15 | 348.3±6.77 | 349.8±11.98 | 339.3±3.77 | 0.720 |
| Renal weight (g) | 1.89±0.04 | 1.88±0.01 | 2.06±0.05 | 1.89±0.05 | 0.093 |
| Renal weight/body weight (*10-3) | 5.48±0.21 | 5.40±0.11 | 5.91±0.18 | 5.56±0.13 | 0.226 |
| Heart rate (beat/min) | 339±10 | 332±17 | 337±10 | 329±9 | 0.943 |
| Systolic blood pressure (mmHg) | 126±1 | 123±3 | 125±4 | 97±3 abc | <0.001 |
| Diastolic blood pressure (mmHg) | 96±1 | 94±1 | 96±2 | 77±2 abc | <0.001 |
| Ejection fraction (%) | 60.6±0.62 | 59.8±1.30 | 31.0±3.11 ab | 39.1±1.77 abc | <0.001 |
| Blood glucose (mmol/L) | 6.5±0.25 | 6.4±0.32 | 5.5±0.22 | 5.8±0.35 | 0.250 |
Data are presented as means ± SEM. P-value based on one-way ANOVA followed by a LSD test. a P < 0.008 vs. normal group; b P < 0.008 vs. sham group; c P < 0.008 vs. MI alone. MI, myocardial infarction; los, losartan.