Figure 4. Uptake of apelin14-liposomes into ECs of B16/BL6 tumors.

(A) Fluorescence microscopic images of B16/BL6 tumor sections from mice administered control liposomes (left) or apelin14-liposomes (right). CD31 (green), rhodamine encapsulated in liposomes (red), and DAPI (blue). Arrowheads indicate liposomes adhering to CD31⁺ ECs but not incorporated into them. Arrows indicate liposomes incorporated into CD31⁺ ECs. Bars indicate 50 µm. (B) Ratio of liposomes incorporated into ECs among all liposomes. Five random fields were observed.