Table 1. Baseline characteristics of the study participants (HIV positive with CD4+ T cell count>350, n = 487).
Parameter | IRF1 619 genotype | p-value | ||
AA | AC | CC | ||
% Total number (n = 487) | 8.9 | 43.1 | 48 | – |
% Female | 100 | 100 | 100 | – |
% Kenyan | 90 | 78 | 69 | – |
% Tanzanian | 10 | 21 | 29 | – |
% Ugandan | – | 1 | 2 | – |
Age (median, IQR) | 42 (34–46.5) | 36 (33–43) | 38 (33–43) | 0.101 |
Follow-up, days (median, IQR) | 2023 (740–3241) | 1462 (351.8–3069.3) | 1746 (469.5–3261.5) | 0.219 |
CD4 counts at baseline (median, IQR) | 508 (407.2–751.5) | 590.5 (447.3–794.8) | 576 (455–708.5) | 0.508 |
No. of CD4 counts/participant (median, IQR) | 9 (3.5–15.5) | 7.5 (3.0–13.8) | 8 (3.0–14.0) | 0.101 |
Treatment | ART-naïve | ART-naïve | ART-naïve | – |
% with VL (n = 263)* | 10.6 | 40 | 49.4 | – |
Average log copies/ml (median, IQR) | 3.1(1.7–4.0) | 3.1(2.0–4.0) | 3.0(1.9–4.2) | 0.9797 |
Standard of care in Kenya does not include HIV VL; these were analyzed on a random subset of patients (total n = 263).